GRANT AWARDS

 

· Pakistan Science Foundation (2006)
(Active Scientist Research Award, 2006; Grant Award: 0.57 million rupees)
Ref: PSF/P&D/A. SC. (115).
Investigator: Dr. Qamar Javed

 

· Leicester Hospitals NHS Trust, U.K. (2002)
   (Ref: Drug-eluting stents, 2002; Grant award: £ sterling 14,000)
    Title: Drug-eluting stents inhibit coronary artery restenosis
Investigators: Dr A Gershlick and Dr. Qamar Javed

 

· Cordis, U.S.A. (2001)
   (Ref: Polmer-coated stents, 2001; Grant award: £ sterling 11,000)
Title: Research on feasibility of coating polymer-coated stents
Investigators: Dr. Qamar Javed and Dr A Gershlick

 

· The British Heart Foundation, U.K. (2000)
   (Ref:   PG/2000111, 2000; Grant award: £ sterling 59,693)
Title: TNF-a antibody and tyrphostin eluting stents to inhibit vascular smooth cell
proliferation
Investigators Dr. Qamar Javed and Dr A Gershlick

 

RESEARCH INTERESTS

(a) Regulation of cytokines expression in the human vascular tissue; the role of inflammatory cytokines in the pathogenesis of cardiovascular disease.

(b) Cytokines Gene polymorphism in relation to cardiovascular disease.

(c) Local drug delivery using drug-eluting stents to limit restenosis in coronary artery; a promising alternative to by-pass surgery in patients suffering from coronary heart disease.

(d) Regulation of gene expression in eukaryotic cells; Role of messenger ribonucleic proteins in the regulation of gene expression.

(e) Regulation of the matricellular proteins during pathological changes in the heart disease patients.

 

M.PHIL STUDENTS SUPERVISED

 

S. No.           Name                                 Title                                                               Viva Date

  1.          Maryam Yousaf       Prevalence of Cardiovascular Risk Factors        07-03-09
in Patients

2.         Tamkina Zar                Study on cardiovascular Disease                             20-08-09

3.         Insiyah Shabbir           Cross Sectional Comparison of Cardiovascular      23-07-09
Risk Factors

4.         Arshad Islam               Cardiovascular Risk Elements in the Asian             17-08-09
Population

5.         Asad Muhammad       Cardiovascular Diseases in Pakistani Population    20-08-09            

PUBLICATIONS

 

Hussain S, Asghar M and Javed Q. Resistin gene promoter region polymorphism and the risk of hypertrophic cardiomyopathy in patients. Translational Research 2010;155(3):142-147.  

Balighi K, Lajevardi V, Moeineddin F, Jelani M, Tamizifar B, Nikoo A, Javed Q, Ahmad W, Parvaneh N. A novel deletion mutation in the human hairless (HR) gene in an Iranian family with atrichia and papular lesions. Clinical and Experimental Dermatology 2009 Oct;34(7):e498-500

 

Swanson N, Hogrefe K, Javed Q, Gershlick AH. In vitro evaluation of vascular endothelial growth factor (VEGF)-eluting stents. International Journal of Cardiology 2003 Dec;92(2-3):247-251.
Swanson N, Hogrefe K, Javed Q, Malik N, Gershlick AH. Vascular Endothelial Growth Factor (VEGF)-Eluting Stents: In Vivo Effects on Thrombosis, Endothelialization and Intimal Hyperplasia. Journal of Invasive Cardiology 2003 Dec;15(12):688-692.
Swanson N, Javed Q, Hogrefe K and Gershlick A. Human internal mammary artery organ culture model of coronary stenting? A novel investigation of smooth muscle cell response to drug-eluting stents. Clinical Science 2002;103(4):347-353.
Javed Q, Swanson N, Vohra H, Thurston H and Gershlick A. Tumor necrosis factor-alpha eluting stents reduce vascular smooth muscle cell proliferation in saphenous vein organ culture Experimental and Molecular Pathology 2002;73(2):104-11.

Javed Q, Spring EL, Gershlick AH and de Bono DP. Plasminogen activator and plasminogen activator inhibitor gene expression in human saphenous vein organ culture.Experimental and Molecular Pathology 2001;70(2):146-53.

Moiseeva EP, Javed Q, Spring EL and de Bono DP. Galactin 1 is involved in vascular smooth muscle cell proliferation. Cardiovascular Research 2000;45:493-502
Javed Q, Leake DS and Weinberg PD. Quantitative immunohistochemical detection of oxidised low density lipoprotein in the rabbit arterial wall. Experimental and Molecular Pathology 1999;65:121-140.
Forster BA, Javed Q. Leake DS and Weinberg PD. High-resolution mapping of the frequency of lipid deposits in thoracic aortas from cholesterol-fed and heritable hyperlipidaemic rabbits. Atherosclerosis 1996;120:249-253.
Fleming TP, Butler L, Lei X, Collins J, Javed Q, Sheth B, Stoddart N, Wild A. and Hay M. Molecular maturation of cell adhesion systems during mouse early development. Histochemistry 1994;101:1-7.
Fleming TP, Javed Q, Collins J, and Hay M. Biogenesis of structural intercellular junctions during cleavage in the mouse embryo. Journal of Cell Science 1993;17: 119-125.
Javed Q, Fleming TP, Hay M and Citi S. Tight junction protein cingulin is expressed by maternal and embryonic genomes during early mouse development. Development 1993;117:1145-1151.
Fleming TP, Hay M., Javed Q and Citi S. Localisation of tight junction protein cingulin is temporally and spatially regulated during early mouse development. Development 1993;117:1135-1144.
Fleming TP, Javed Q and Hay M. Epithelial differentiation and intercellular junction formation in the mouse early embryo. Development Suppl 1992;105-112.
Javed Q, Newton RP and Ratcliffe NA. A novel plasma factor that potentate prophenoloxidase activation in the immune response of Blaberus discoidalis. Biochemical Society Transactions. 1990;18(3):457.
Javed Q and Merrett MJ. Mobilisation of NADPH glutamate dehydrogenase mRNA in regreening cultures of Euglena gracilis. Plant Science 1987;49:31-36.
Javed Q and Merrett MJ. Properties and immunochemical characterisation of NADPH-specific glutamate dehydrogenase from Euglena gracilis. New Phytology 1986; 104:407-413.
Fayyaz-Chaudhary M, Javed Q and Merrett MJ. Effect of growth conditions on NADPH-specific glutamate dehydrogenase activity of Euglena gracilis. New Phytology 1985;101:367-376.
Parker JE, Javed Q and Merrett MJ. Glutamate dehydrogenase (NADP-dependent) mRNA in relation to enzyme synthesis in Euglena gracilis.
Evidence for posttranscriptional control. European Journal of Biochemistry 1985;153:573-578.

 

PUBLICATIONS FROM INTERNATIONAL CONFERENCES

Swanson N, Hogrefe K, Malik N, Javed Q and Gershlick A. Vascular endothelial growth factor (VEGF) - eluting stents. In vivo assessment of effects on thrombosis, endothelialisation and restenosis. British Cardiac Society Conference, Glasgow, U.K., 2002.

Swanson N, Javed Q, Hogrefe K, Gershlick A. Human arterial organ culture model of drug-eluting stents to reduce restenosis. Abstract 173 accepted for British Cardiac Society Conference, Glasgow, U.K., 2001.
Swanson N, Hogrefe K, Javed Q, Azrin MA and Gershlick AH. VEGF-eluting stents stimulate endothelial cell growth in vitro. Journal of American College of Cardiology 2001;37(Suppl A):1A 1038-12.
Swanson NM, Javed Q, Hogrefe K and Gershlick AH. VEGF-eluting coronary stents stimulate endothelial growth in vitro. Journal of Submicroscopic Cytology and Pathology 2000;32 (3) 419 B087.
Swanson N, Baron JH, Hogrefe K Javed Q and Gershlick AH. Novel delivery of vascular endothelial growth factor delivery using polymer-coated stents: loading and elution characteristics. British Cardiac Society Conference, Glasgow, U.K., 15-18 May 2000. Heart 83 (Suppl 1 P28).
Swanson N, Hogrefe K, Baron J, Javed Q and Gershlick A. VEGF-eluting stents to reduce stent complications – pharmacokinetics of adsorption and elution. 6th International LDD&R Local Drug delivery meeting and cardiovascular course on Radiation & Molecular Strategies – Abstract Book. January 2000.
N Swanson, K Hogrefe, Q Javed, AH Gershlick. Drug-eluting stents – could drugs tailored to the patient be loaded in the catheter lab?
European Heart Journal 2000;21(Suppl) P1601
Javed Q, Spring EL, Gershlick AH and de Bono DP. Plasminogen activator and Plasminogen activator inhibitor expression in vascular organ culture. European Heart Journal 1999;20(Suppl):42 P410.
Moiseeva EP, Javed Q, Spring EL and de Bono DP. Galactin 1 modifies growth of vascular smooth muscle cell. European Heart Journal 1999;20 (Suppl):64 P498.
Javed Q, Leake DS and Weinberg PD. Quantitative immunolocalisation of oxidised low density lipoprotein in the rabbit aortic wall. Atherosclerosis (Suppl) 1995;115:15.
Fleming TP, Javed Q and Hay M. Epithelial junction maturation during early mouse development. Joint Spring Meeting of British Society for Cell Biology and British Society for Developmental Biology, University of Sussex, Brighton, 7-10 April, 1992.
Javed Q, Fleming TP and Hay M. Expression of tight junction protein cingulin during early mouse development. The Seventh International Conference of the International Society of Differentiation, Helsinki, Finland, 19-23 July, 1992.

 

 

Contact Information

Biochemistry Department QAU Islamabad Pakistan
Phone: 05190643169
E-mail: baqi.qau@gmail.com

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